Programme

Day 1 (6 September)

15.00-17.00
Registration

17.00-17.15
Welcome session and practical information
Carlo Marobbio

17.15-18.00
Opening Lecture:
John Walker (Nobel Laureate) – introduced by Carlo Marobbio
Similarities and differences between yeast and mammalian ATP synthases

18.00-18.50
In commemoration of André Goffeau:
Pierre Morsomme & Elisabetta Balzi

18.50-19.30
Marcelle Grenson Lecture:
Rosine Hagauenauer-Tsapis
Ubiquitylation events in yeast plasma membrane transporters trafficking: essential contribution of Grenson’s mutants

Day 2 (7 September)

Session 1. Structure-function relationships and evolution of transporters
(Chairs Bruno André and George Diallinas)

9.00-9.40
Nico Van Uden Lecture:
Peter Henderson
In, out and roundabout: the dynamics of nucleobase transport across membranes

9.40-10.05
Bernadette Byrne

Role of lipids in the structure and function of uric acid/xanthine transporter, UapA, from Aspergillus nidulans

10.05-10.30
Pierre Falson

Detergent design and control for improving the structure resolution of membrane proteins

10.30-10.55
George Diallinas

Tales of tails in transporters or how cytosolic termini control membrane trafficking, turnover and transport function

10.55-11.15
Coffee break

11.15-11.40
Jost Ludwig

The “Long Hydrophilic Loop (LHL)” in the Saccharomyces cerevisiae K+ translocation system Trk1 might act as regulator of ion fluxes

11.40-12.05
Ioanna Myronidi

Amino acid permease folding requires the ER membrane-localized chaperone Shr3

12.05-12.30
Zhiqiang Zhang

Identification of Gap1p and Gcd6p interaction domains using peptide screening in Saccharomyces cerevisiae

12.30-12.55
Fenella Steyfkens

Physiological relevance of the in vivo Gap1 transceptor-eIF2(B) interaction using bimolecular fluorescence complementation

12.55-15.00
Lunch Break and Posters

15.00-15.40
Plenary lecture:
Barbara Halkier
Origin and evolution of a transporter substrate specificity

15.40-16.05
Claudio Scazzocchio
Fungal metabolic gene clusters: a view from transporters

16.05-16.20
Coffee break

Session 2. Mechanisms of membrane traffic and turnover of transporters
(Chairs Sandra Paiva & Markus Babst)

16.20 – 17.00
Plenary lecture:
Sebastien Leon
Regulation of Transporter Endocytosis by Glucose-Signaling Pathways through the Regulation of Arrestin-Related Proteins

17.00-17.25
Sandra Paiva

Signals and mechanisms of endocytosis of eukaryotic lactate transporters

17.25-17.50
Olga Martzoukou
The AP-1 complex is essential for fungal growth via its role in secretory vesicle polar sorting, endosomal recycling and cytoskeleton organization

17.50-18.15
Olga Zimmermannová
Erv14 cargo receptor participates in the regulation of potassium homeostasis via its interaction with K+ specific transporters Trk1 and Tok1

Day 3 (8 September- half day)

Session 3. Transporters in cell regulation, physiology and signaling
(Chairs José Ramos and Catarina Prista)

8.45-9.10
Zdena Palkova
Development and differentiation of yeast colonies: Regulation of membrane transporters by mitochondrial signaling

9.10-9.35
Bruno André
TORC1 at the crossroads of nutrient transporter regulation in yeast

9.35-10.00
Joaquin Arino
Deciphering the molecular basis of toxicity of yeast phosphatase Ppz1

10.00-10.25
Rogelio Lopes Brandão

The role of calcium signaling in plasma membrane H+-ATPase activation in Saccharomyces cerevisiae cells

10.25-10.50
José Ramos
The diversity of plasma membrane potassium transporters in Candida yeasts

10.50-11.10
Coffee break

11.10-11.50
Plenary Lecture:
Rajini Rao
Epigenetic control of endosomal pH by Na+/H+ exchangers is conserved from yeast to human

11.50-12.15
Antoine Deschamps
How is ion and pH homeostasis regulated in the Golgi apparatus? Involvement of a new Ca2+ – Mn2+ / H+ transporter

12.15-12.40
Louise Thines
The yeast Gdt1p transports Mn2+ and thereby regulates manganese homeostasis at the Golgi

12.40-13.05
Melody Cools
Study of the arginine transporters of the yeast vacuole provides insight into their regulation

13.05-15.00
Lunch Break followed by organized excursion and gala dinner

Day 4 (9 September)

Session 4. Mitochondria and Transporters
(Chairs Carlo Marobbio and Milan Hoefer)

9.00-9.40
Plenary lecture:
Luigi Palmieri
The mitochondrial carrier family in Saccharomyces cerevisiae: small is great

9.40-10.05
Edmund Kunji

The structural mechanism of adenine nucleotide transport by the mitochondrial ADP/ATP carrier

10.05-10.30
Gennaro Agrimi

Role of mitochondrial carriers in organic acid production

10.30-10.55
Dominik Jeschek

Unraveling transport mechanisms of mitochondrial carrier proteins to develop new metabolic engineering strategies

10.55-11.15
Coffee break

11.15-11.55
Plenary lecture:
Per O. Ljungdahl
Mitochondrial proline metabolism energizes the escape of Candida albicans from macrophages

11.55-12.20
Dmitry Knorre

Regulation of multiple drug resistance: a possible connection between ergosterol biosynthesis and mitochondria

12.20-12.45
Markus Babst

Nutrient Uptake by APC-Transporters is Linked to Mitochondrial Respiration

12.45-13.10
Nicoletta Guaragnella

Nutritional status differentially regulates mitochondrial retrograde signaling in yeast

13.10-15.10
Lunch Break and Posters

Session 5. Transporters in drug action and as tools
(Chairs Joaquin Arino & Rajendra Prasad)

15.10-15.35
Rajendra Prasad
Vacuolar sequestration of azoles: A novel strategy of azole antifungal resistance conserved across pathogenic and non-pathogenic yeast

15.35-16.00
Sina Schmid

Saccharomyces cerevisiae hxt0 strains serve as research and high-throughput ligand screening platform for the human glucose transporters GLUT1-5

16.00-16.15
Coffee break

16.15- 16.35
Sebastian Tamayo Rojas
Prevention of glucose induced down-regulation of the engineered hexose/xylose transporter Gal2

16.35-17.05
Matthias Steiger

Identification of the citrate exporter CexA for citric acid production in Aspergillus niger

17.05-17.30
Milan Hoefer

Is the membrane potential capable of driving potassium uptake in yeast?

17.30-18.00
Concluding Remarks (Milan Hoefer) & Presentation of SMYTE37 (Jost Ludwig)